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GENETIC STRUCTURE-FUNCTION ANALYSIS OF THE ESSENTIAL GLYCOPROTEIN GB IN HERPES SIMPLEX VIRUS TYPE 1-INDUCED MEMBRANE FUSION (VIRAL MEMBRANE PROTEIN).
註釋A genetic structure-function analysis of the essential HSV-1 membrane glycoprotein gB transmembrane and cytoplasmic domains in virally-induced membrane fusion was performed. Membrane fusion is induced at two times during infection: (i) early, between the virion envelope and cellular plasma membrane to initiate infection and (ii) late, between adjacent cells. Certain mutant HSV strains induce extensive cell fusion, or syncytia (syn) during infection. Syn mutations have been identified within the gB