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Relationships of Blood and Brain Halocarbon Solvent Concentrations to Neurobehavioral Toxicity

David Alan Warren

出版	University of Georgia, 1995
URL	http://books.google.com.hk/books?id=10MyqwZVMs0C&hl=&source=gbs_api
EBook	FULL_PUBLIC_DOMAIN

註釋

Time-courses of blood and brain concentrations and neurobehavioral toxicity were determined for two halocarbon solvents in two rodent species. Based on these data, quantitative relationships, or the lack thereof, have been reported between the degree of neurobehavioral toxicity and internal measures of dose. In the case of orally- administered perchloroethylene (PCE), relationships between blood and brain concentrations and operant performance were not discernable, due in part to an acute adaptation of rats to PCE's response suppressing effect. For inhaled 1,1,1- trichloroethane (TRI), blood and brain concentrations were strongly correlated with the rate of operant responding in rats.