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Cognitive Heterogeneity in Autism Spectrum Disorders

其他書名	Linking Complex Behavior, Function, and Neuronal Integrity
出版	University of California, San Diego, and San Diego State University, 2005
URL	http://books.google.com.hk/books?id=1NgYKPlDlIMC&hl=&source=gbs_api

註釋Progress has been made in characterizing cognitive functioning and the neurological basis of autism spectrum disorders (ASD) disorders, although few studies have directly linked cognitive deficits with neural defects. Complex behavior, brain function, and neuronal integrity were investigated in high-functioning (FSIQ>70) males with ASD. The Color-Word Interference Test, Trail Making Test, Verbal Fluency Test, and Design Fluency Test from the Delis-Kaplan Executive Function System were administered to 12 ASD individuals [age = (26.4(7.7)]. Participants performed below average on the executive function composite (p = .02). Letter and category switching fluency produced the most consistent deficits (i.e., SS8); cognitive inhibition and semantic fluency were intact. The neurofunctional basis of intact category and impaired letter fluency was investigated using FMRI. Fourteen ASD [age = 23.8(9.6)] and 14 controls [age = 22.4(8.7)] participated. The ASD group had greater right prefrontal and temporal activation in letter fluency (p