返回Google圖書搜尋

Controlling Osteoblast Morphology and Proliferation Via Surface Micro-topographies of Implant Biomaterials

Kerstin RabelRalf-Joachim KohalThorsten SteinbergPascal TomakidiBernd RolauffsErik AdolfssonPaola PalmeroTobias FürdererBrigitte Altmann

出版	Universität, 2020
URL	http://books.google.com.hk/books?id=1RPzzQEACAAJ&hl=&source=gbs_api

註釋Abstract: Current research on surface modifications has yielded advanced implant biomaterials. Various implant surface modifications have been shown to be promising in improving bone target cell response, but more comprehensive studies whether certain implant surface modifications can directly target cell behavioural features such as morphogenesis and proliferation are needed. Here, we studied the response of primary alveolar bone cells on various implant surface modifications in terms of osteoblast morphology and proliferation in vitro. Analyses of surface modifications led to surface-related test parameters including the topographical parameters micro-roughness, texture aspect and surface enlargement as well as the physicochemical parameter surface wettability. We compared osteoblast morphology and proliferation towards the above-mentioned parameters and found that texture aspect and surface enlargement but not surface roughness or wettability exhibited significant impact on osteoblast morphology and proliferation. Detailed analysis revealed osteoblast proliferation as a function of cell morphology, substantiated by an osteoblast size- and morphology-dependent increase in mitotic activity. These findings show that implant surface topography controls cell behavioural morphology and subsequently cell proliferation, thereby opening the road for cell instructive biomaterials