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SYNTHESES OF ALIPHATIC EPOXIDES FOR MUTAGENICITY STUDIES.

SUBHASH CHANDRA AIRY

出版	University of MICHIGAN, 1982
URL	http://books.google.com.hk/books?id=2T5tAAAAMAAJ&hl=&source=gbs_api

註釋

The present study concerns the development of structure-mutagenicity relationships for aliphatic epoxides. Several mono-substituted propylene oxide derivatives were synthesized by nucleophilic displacement of the substituent group X(-Br or -I) by an appropriate ambient nucleophile. Nucleophilic displacement reactions using phase transfer catalysts such as dibenzo-18-crown-6 yielded only 1-iodo-2,3-propylene oxide from 1-bromo-2,3-propylene oxide. 1,1-Disubstituted epoxides such as 1-phenylstyrene oxide