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Biological DNA Sensor
Søren R. Paludan
Andrew G. Bowie
其他書名
Chapter 8. Viral Infections and the DNA Sensing Pathway: Lessons from Herpesviruses and Beyond
出版
Elsevier Inc. Chapters
, 2013-10-30
主題
Medical / Immunology
Science / Life Sciences / Microbiology
ISBN
0128068817
9780128068816
URL
http://books.google.com.hk/books?id=2YhzDAAAQBAJ&hl=&source=gbs_api
EBook
SAMPLE
註釋
Microbial and host DNA are potent stimulators of innate immune responses and have been implicated in both host defense and autoimmune diseases. To date more than 10 immunological sensors of DNA have been proposed, and we are now beginning to understand the functions and mechanism of action of these proposed DNA sensors in host defense and diseases. Much of the current knowledge on DNA sensing has been obtained through studies with herpesviruses. Hence, in this chapter, we review and critically assess the literature on innate DNA recognition from the perspective of herpesviruses sensing. Finally, we extend the discussion beyond herpesviruses, and propose important questions that need to be addressed in the emerging field of innate immune activation by DNA.