Peeking at the Association of Y Chromosomal Loss with various Men's Health Problem.

Although Y chromosomal genes are involved in male sex development, spermatogenesis, and height growth, these genes play no role in the survival or mitosis of somatic cells.    

     Therefore, somatic cells lacking the Y chromosome can stay and proliferate in the body.

     Several molecular technologies, including next-generation sequencing and multiplex PCR-based assays, are used to detect mosaic loss of the Y chromosome (mLOY) in the blood of men.

     Accumulating evidence suggests that mLOY represents the most common acquired chromosomal alteration in humans, affecting >40% of men over 70 years of age.

    Some other factors are also known to increase the frequency of mLOY.

    The developmental process of mLOY in elderly men remains to be clarified.

     Further, MLOY has been associated with:

·   Early death,

·   Cancers, and

·   Other disorders:

§ In Elderly Men,

§ Infertility in Reproductive-aged Men, and

§ Developmental defects in Children.

      To conclude, Y chromosomes in men can be lost at every life stage and Y chromosomal loss is associated with various health problems.

      Thus an attempt has been made in this Booklet to introduce possible aetiologies and phenotypic consequences of mLOY along with several ILLUSTRATIONS and Tables for better understanding.

…Dr. H. K. Saboowala.  

             M.B.(Bom) .M.R.S.H.(London)