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Corneal Endothelium in Silicone Hydrogel and Gas Permeable Contact Lens Wearers

出版	Northeastern State University, 2016
URL	http://books.google.com.hk/books?id=40P8swEACAAJ&hl=&source=gbs_api

註釋Purpose. The corneal endothelium primarily functions to maintain corneal clarity. In the presence of certain stressors the endothelial mosaic can be disrupted resulting in polymegathism, pleomorphism, decreased function, and cell loss. Contact lens wear has been shown to alter the endothelial mosaic. Our purpose was to determine if newer silicone hydrogels have less of an effect on the endothelium than rigid gas permeable lenses. Methods. We examined the endothelial mosaic of 28 contact lens wearers. Fourteen patients were SiHy wearers, and the others were RGP wearers. We assessed the ECD, COV, percentage of hexagonal cells, and CCT in the two groups of subjects. Results. A t-test failed to show a statistically significant difference between RGP and SiHy wearers in the areas of ECD, COV, CCT, and also in a comparison of ECD of soft and rigid lens wearers having an ECD below expected age norms. T-tests also showed the percentage of hexagonal cells was significantly less for rigid lenses than for SiHy lenses for right eyes but not for left eyes based on unpaired t-tests. Chi-squared testing failed to show a statistically significant difference in the two groups when comparing material versus ECD by age norms, years of wear versus ECD by age norms, and material versus COV. Conclusion. According to our research, no statistically significant endothelial health advantage is apparent when comparing RGP and SiHy lenses. It appears patients fit in either type of lens would have comparable endothelial health when assessing the variables contained within this study.