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Total Synthesis of Natural Products with Antimicrobial Activity
Andrew Giltrap
出版
Springer
, 2018-05-02
主題
Science / Chemistry / Clinical
Medical / Biochemistry
Medical / Pharmacology
Science / Life Sciences / Biochemistry
Medical / General
ISBN
9811088063
9789811088063
URL
http://books.google.com.hk/books?id=43ZZDwAAQBAJ&hl=&source=gbs_api
EBook
SAMPLE
註釋
This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) – teixobactin and the skyllamycins – with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the
Pseudomonas aeruginosa
biofilms that are responsible for significant mortality among cystic fibrosis patients.