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出版American Diabetes Association, 2020
URLhttp://books.google.com.hk/books?id=4_GRzgEACAAJ&hl=&source=gbs_api
註釋Objective To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes (T1D). Research design and methods Twenty participants with T1D (aged 14.646 1.78 years) and 20 age-matched healthy control subjects (aged 14.4062.82 years) performed two functional MRI sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L [360 mg/dL]). Results Lower spatial working memory (sWM) capacity during acute hyperglycemia and significant differences in activation of regions of interest during different stages of the sWM task (P 5 0.014) were observed. Conclusions Acute hyperglycemia negatively affected sWM capacity in adolescents with T1D, which is relevant for daily functioning and academic performance.