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Advances in Molecular Toxicology
Arno G. Siraki
其他書名
Chapter Two. Free Radical Metabolites in Arylamine Toxicity
出版Elsevier Inc. Chapters, 2013-08-12
主題Medical / GeneralScience / Environmental ScienceMedical / PharmacologyTechnology & Engineering / Chemical & BiochemicalScience / Chemistry / GeneralScience / BiotechnologyScience / Chemistry / Industrial & TechnicalMedical / ToxicologyMedical / Internal Medicine
ISBN01280849449780128084946
URLhttp://books.google.com.hk/books?id=5YZ1DAAAQBAJ&hl=&source=gbs_api
EBookSAMPLE
註釋Aromatic amines (also known as arylamines) form a very important class of xenobiotics. The arylamine substructure is found in pesticides, carcinogens, and drugs. It is therefore unsurprising that arylamine drugs possess varying degrees of toxicity which ultimately depend on dose, exposure, and the particular genetic makeup of the individual. Arylamines have been shown to undergo oxidation reactions to produce reactive metabolites. This chapter will focus on a subset of reactive metabolites which are the arylamine-free radical metabolites. A detailed discussion on how these free radical metabolites form is presented, and association between the latter and toxicity reactions are discussed. Particular emphasis is devoted to the subject of arylamine-induced blood dyscrasias and recent advances as well as future prospects in this area.