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Rhodium‐catalyzed Cyclization of Terminal and Internal Allenols: an Atom Economic and Highly Stereoselective Access Towards Tetrahydropyrans

出版	Universität, 2020
URL	http://books.google.com.hk/books?id=6c9GzgEACAAJ&hl=&source=gbs_api

註釋Abstract: A comprehensive study of a diastereoselective Rh-catalyzed cyclization of terminal and internal allenols is reported. The methodology allows the atom economic and highly syn-selective access to synthetically important 2,4-disubstituted and 2,4,6-trisubstituted tetrahydropyrans (THP). Furthermore, its utility and versatility are demonstrated by a great functional-group compatibility and the enantioselective total synthesis of (−)-centrolobine