Differences/Similarities Between Epistatic Gene and Hypostatic Gene.

                                    A Concise Overview.

Epistasis occurs if the effect of one variant affecting a complex trait depends on the genotype of a second variant affecting the trait.

      For example, consider two loci (A, B), each with two alleles (A1, A2, B1, B2).      

      Epistasis would occur, for example, if the A2A2B2B2 genotype had a high disease risk, but the eight other possible two-locus genotypes had no effect on risk.

    This is only one of many possible forms of epistatic interactions between two loci. 

    Epistasis is one of several non-mutually exclusive explanations for small effects, missing heritability and lack of replication of top trait-associated variants in different populations in human genome-wide association studies.

      Determining epistatic gene action in the context of human disease will improve our understanding of the biological systems that underpin variation in disease risk as well as increase the accuracy of individual risk prediction.

     Thus, in context with the disease risk as well as increase the accuracy of individual risk prediction, it is endeavoured to address the following key questions/points precisely along with several relevant ILLUSTRATIONS/Table for the busy medicos at one click:

1. Introduction.

2. What is Epistatic Gene?

3. What is Hypostatic Gene?

4. Similarities Between Epistatic Gene  

    and Hypostatic Gene.

5. Side by Side Comparison – Epistatic  

    Gene vs Hypostatic Gene in Tabular   

    Form.

6. Summary.

  …Dr. H. K. Saboowala.

              M.B.(Bom) .M.R.S.H.(London)