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Preparation of Nanosized Pharmaceutical Formulations by Dual Centrifugation

Jonas K. KoehlerStefanie SchmagerValentin BenderDenise SteinerUlrich Massing

出版	Universität, 2023
URL	http://books.google.com.hk/books?id=779t0AEACAAJ&hl=&source=gbs_api

註釋Abstract: Dual centrifugation (DC) is an innovative in-vial homogenization and in-vial nanomilling technique that has been in use for the preparation of liposomes for more than one decade. Since then, DC has continuously been developed for preparing various liposomes and other lipid nanoparticles including emulsions and solid lipid nanoparticles (SLNs) as well as polymersomes and nanocrystals. Improvements in equipment technology have been achieved over the past decade, so that DC is now on its way to becoming the quasi-standard for the simple, fast, and aseptic production of lipid nanoparticles and nanocrystals in small and medium batch sizes, including the possibility of simple and fast formulation screening or bedside preparations of therapeutic nanoparticles. More than 68 publications in which DC was used to produce nanoparticles have appeared since then, justifying an initial review of the use of DC for pharmaceutical nanotechnology