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Structure of SWI/SNF Chromatin Remodeller RSC Bound to a Nucleosome and Implications for Chromatin Remodelling

Felix Roman Wagner

出版	Georg-August-Universität Göttingen, 2020
URL	http://books.google.com.hk/books?id=7FR00AEACAAJ&hl=&source=gbs_api

註釋

Eukaryotic cells condense their DNA into chromatin, which hampers the accessibility of genetic information. Nucleosomes are the smallest building blocks of chromatin and are comprised of an octameric core of histone proteins, around which 145 - 147 base pairs of DNA are tightly wrapped. Fundamental cellular processes such as transcription require free DNA devoid of nucleosomes. To that end, chromatin remodellers are employed to manoeuvre nucleosomes, providing the cell with means to regulate gene expression through DNA accessibility. These large molecular machines are grouped into four fami...