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The Effects of Leucine Deprivation and Caloric Restriction on the Human Metabolism

出版	Pennsylvania State University, 2010
URL	http://books.google.com.hk/books?id=7OWkAQAACAAJ&hl=&source=gbs_api

註釋Recent studies have shown repressed lipid synthesis and substantially reduced adiposity in mice deprived of the essential amino acid leucine. A two week dietary intervention was conducted with 36 females and 13 males at The Pennsylvania State University GCRC to determine if a low-leucine diet in humans would result in rapid reduction of adipose tissue and increased insulin sensitivity. The control group was given a 25% caloric restricted diet with normal (100% RDA) leucine levels, and the experimental group was given a 25% caloric restricted diet deficient in leucine (7% RDA). It was hypothesized that leucine deficiency in humans would stimulate a starvation response, similar to that observed in mice. The effects of both leucine deficiency and caloric restriction were analyzed for a number of anthropometric and metabolic response variables. A comprehensive statistical analysis included a one-way ANCOVA to determine the effects of leucine deficiency and a repeated measures ANOVA to determine the effects of caloric restriction. To further investigate the metabolic consequences of the diets on the associations between the responses, partial correlation analyses were conducted between the percent changes of every combination of variables for both 100% leucine and 7% leucine diets, and another pair of partial correlation analyses were done for Day 0 and Day 14, with the data for both diets combined. The results showed no differences that passed the Bonferroni adjusted significance threshold in the mean responses between the groups given different leucine amounts in their diets. Those that passed the p