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Transformation of Human Epithelial CellsMolecular and Oncogenetic Mechanisms
George E. MiloBruce C. CastoCharles F. Shuler
出版CRC Press, 1992-02-03
主題Science / Life Sciences / Cell BiologyMedical / Oncology / GeneralScience / Life Sciences / Molecular Biology
ISBN08493638299780849363825
URLhttp://books.google.com.hk/books?id=7_kiNgWNGpgC&hl=&source=gbs_api
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註釋This book offers a conceptual explanation of the interrelationships that exist between the stages in the progression of initiated epithelial cells in culture compared with the diverse tissue of organs and the progression of tumors from different organ sites. The fate of the modification of adducts is discussed at the molecular level. The role that modifications in hot spots in oncogenes and supressor genes play at the molecular level and how these molecular modifications can lead to an explanation of molecular control in the formation of tumor phenotypes is also examined. Researchers in cell biology and toxicology, applied pharmacology, carcinogenesis, teratogenesis, mutagenesis, and molecular toxicology will find the book useful, interesting reading.