登入選單
返回Google圖書搜尋
Post-translational Regulation of XPC in Repair of UV-Induced DNA Damage
Palak Shah
出版ProQuest Dissertations & Theses, 2018
ISBN04380841879780438084186
URLhttp://books.google.com.hk/books?id=86XDwgEACAAJ&hl=&source=gbs_api
註釋We also found that phosphorylation of XPC acts as a novel post-translational regulatory mechanism of the NER pathway. We show that XPC is phosphorylated at serine 94. Moreover, after UVB irradiation, XPC phosphorylation regulates recruitment of ubiquitinated XPC and its downstream NER factors to the chromatin. In addition, upon evaluating the predicted kinases for XPC phosphorylation, we found that casein kinase II (CK2) promotes NER. Furthermore, CK2 kinase mediates XPC phosphorylation at serine 94, and also promotes recruitment of ubiquitinated XPC to the chromatin after UVB irradiation. Our findings have identified XPC phosphorylation as a new mechanism for regulating NER following UV-induced DNA damage.