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Xenobiotic Metabolism and Disposition
Harry P.A. Illing
其他書名
The Design of Studies on Novel Compounds
出版CRC Press, 2019-11-11
主題Medical / PharmacologyMedical / ToxicologyScience / Life Sciences / GeneralScience / Chemistry / Toxicology
ISBN100071456X9781000714562
URLhttp://books.google.com.hk/books?id=8WK-DwAAQBAJ&hl=&source=gbs_api
EBookSAMPLE
註釋This publication explains the principles of the techniques used in disposition and metabolism studies in animals, in man, and in vitro. It includes methods for studying routes and rates of absorption, distribution, metabolism, and excretion of novel compounds and their metabolites. Relevant surgical, whole-body autoradiographic and pharmacokinetic procedures are discussed, together with techniques for separating and identifying metabolites and metabolic path-ways. Information on when the procedures are appropriate, and examples of what they represent, are presented in order to illustrate the value of such studies.