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Changes in the Propofol-Induced Frontal Electroencephalogram in Children With Autism Spectrum Disorder

Elisa Claire Walsh

出版	Harvard University, 2017
URL	http://books.google.com.hk/books?id=8XRntAEACAAJ&hl=&source=gbs_api

註釋

General anesthetic drugs induce characteristic oscillations within brain circuits that can be readily assessed using the electroencephalogram (EEG), allowing a controlled and noninvasive way to study the circuitry of the human brain. During propofol-induced unconsciousness, frontal EEG demonstrates large-amplitude slow-delta oscillations (0.1-4 Hz) and frontally coherent alpha oscillations (8-13 Hz), the latter of which are thought to reflect propofol's actions within frontal thalamocortical circuits. Previous studies from our laboratory show significant age-related changes in the propofol-induced frontal EEG that are thought to reflect the development of underlying circuits mediated by GABAergic interneurons. Interestingly, autism spectrum disorder (ASD) is increasingly seen in the clinical setting and is thought to arise from deficits in GABAergic signaling leading to abnormal neurodevelopment and neuromodulation.