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BIOCHEMICAL BASIS FOR THE ANTI-HERPES AND CYTOTOXIC ACTIVITIES OF NITROGEN(4)-DERIVATIVES OF 2-ACETYLPYRIDINE THIOSEMICARBAZONE (ANTIVIRAL, RIBONUCLEOTIDE, REDUCTASE).

STEVEN ROBERT TURK

出版	University of MICHIGAN, 1985
URL	http://books.google.com.hk/books?id=8khxAQAACAAJ&hl=&source=gbs_api

註釋

After characterization of the viral and cellular reductases, the effects of five derivatives of 2-acetylpyridine thiosemicarbazone on the two enzymes were examined. All five derivatives were potent inhibitors of the viral reductase. Furthermore, three of the derivatives were found to be more potent as inhibitors of the viral reductase by a factor of 2, 8, and >35, based on a comparison of 50% inhibitory concentrations. Kinetic studies indicated that inhibition of the viral reductase was not competitive