返回Google圖書搜尋

Opioid Effects on Palatability in the Nucleus Accumbens

出版	University of California, San Francisco, 2005
ISBN	05421999399780542199936
URL	http://books.google.com.hk/books?id=8pUw-JW8KEQC&hl=&source=gbs_api

註釋We found that infusion of a MOP-specific agonist into the NAcc eliminated SSS; this effect occurred through a preferential increase in consumption of the pre-fed food. Conversely, blockade of endogenous opioid signaling in the NAcc by naltrexone infusion increased SSS; this effect was mediated by a selective decrease in consumption of the pre-fed food. Additionally, if a delay is introduced between pre-feeding and micro-injection, DAMGO no longer blocks SSS indicating that concomitant food-DAMGO pairing is critical for this effect. Taken together, these effects demonstrate that endogenous opioid signaling within the NAcc condition flavor preferences. However, infra-NAcc DAMGO does not cause long term changes in flavor preference; after a three hour delay no effect remains. Finally, micro-injection of DAMGO into an offsite control in the dorsal striatum, systemic injection of opioid agonists and antagonists and infusion of a GABA agonist into the NAcc modulate feeding but have no effect on SSS highlighting the importance of infra-NAcc opioid receptors for flavor conditioning.