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Comparison of Driving Simulator Performance and Neuropsychological Testing in Narcolepsy

出版	2004
URL	http://books.google.com.hk/books?id=8uMrngEACAAJ&hl=&source=gbs_api

註釋Daytime sleepiness and cataplexy can increase automobile accident rates in narcolepsy. Several countries have produced guidelines for issuing a driving license. The aim of the study was to compare driving simulator performance and neuropsychological test results in narcolepsy in order to evaluate their predictive value regarding driving ability. Thirteen patients with narcolepsy (age: 41.5±12.9 years) and 10 healthy control patients (age: 55.1+7.8 years) were investigated. By computer-assisted neuropsychological testing, vigilance, alertness and divided attention were assessed. In a driving simulator patients and controls had to drive on a highway for 60 min (mean speed of 100 km/h). Different weather and daytime conditions and obstacles were presented. Epworth Sleepiness Scale-Scores were significantly raised (narcolepsy patients: 16.7±5.1, controls: 6.6±3.6, P=0.001). The accident rate of the control patients increased (3.2±1.8 versus 1.3±1.5, P=0.01). Significant differences in concentration lapses (e.g. tracking errors and deviation from speed limit) could not be revealed (9.5±3.5 versus 7.1±3.2, pns). Follow-up investigation in five patients after an optimising therapy could demonstrate the decrease in accidents due to concentration lapses (P