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Architectural B-cell Organization in Skeletal Muscle Identifies Subtypes of Dermatomyositis

Josefine RadkeRandi KollCorinna PreußeDebora PehlKremena TodorovaConstanze SchönemannYves AllenbachEleonora M.A AronicaMarianne de VisserFrank L. HeppnerJoachim WeisSoroush DoostkamThierry MaisonobeOlivier BenvenisteHans Hilmar GoebelWerner Stenzel

出版	Universität, 2018
URL	http://books.google.com.hk/books?id=8xVh0AEACAAJ&hl=&source=gbs_api

註釋Abstract: Objective:
To study the B-cell content, organization, and existence of distinct B-cell subpopulations in relation to the expression of type 1 interferon signature related genes in dermatomyositis (DM).

Methods:
Evaluation of skeletal muscle biopsies from patients with adult DM (aDM) and juvenile DM (jDM) by histology, immunohistochemistry, electron microscopy, and quantitative reverse-transcription PCR.

Results:
We defined 3 aDM subgroups--classic (containing occasional B cells without clusters), B-cell-rich, and follicle-like aDM--further elucidating IM B-lymphocyte maturation and immunity. The quantity of B cells and formation of ectopic lymphoid structures in a subset of patients with aDM were associated with a specific profile of cytokines and chemokines involved in lymphoid neogenesis. Levels of type 1 interferon signature related gene expression paralleled B-cell content and architectural organization and link B-cell immunity to the interferon type I signature.

Conclusion:
These data corroborate the important role of B cells in DM, highlighting the direct link between humoral mechanisms as key players in B-cell immunity and the role of type I interferon-related immunity