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CHEMISTRY OF ADVANCED MATERIALS
註釋Piperazine core has the unique structural feature which is widely exploited in medicinal chemistry. Substitution on piperazine provides a way to build library of compound which are bioactive. Bioactivity of piperazine core has been utilised in manufacturing of many classes of drugs which are commercially available. Structures of these drugs contain piperazine unit with either one side substitution or both, thus this small unit provide a unique way to builda huge library of compounds. Therapeutic action of these drugs provides significant breakthrough in providing the mechanism for prevention of fatal diseases. Here we present a few classes of drugs containing piperazine moiety and discussed their therapeutic action in the living system