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ASSOCIATION BETWEEN EARLY-ONSET CRYPTOGENIC ISCHEMIC STROKE AND MIGRAINE SUBTYPES IN THE SECRETO STUDY

Nicolas Martinez-Majander

出版	2017
URL	http://books.google.com.hk/books?id=9p-vzQEACAAJ&hl=&source=gbs_api

註釋

Background: Approximately one third of ischemic strokes in the young remain cryptogenic after an extensive diagnostic work-up. Migraine is a frequent feature in these early-onset cryptogenic ischemic strokes (CIS) yet its association has not been consistently shown specifically in this patient group. We assessed the association between migraine and its subtypes and early-onset CIS, with subgroup analyses stratified by sex.Methods: We prospectively enrolled 213 patients aged 18-49 with imaging-positive acute CIS and 213 age- and sex-matched healthy controls in the ongoing international multicenter SECRETO study (NCT01934725). Screening and characterization of any migraine and migraine with and without aura (MA and MO, respectively) were performed using a novel validated questionnaire including 17 questions. To study the associations, we used conditional logistic regression adjusting for variables with P