登入
選單
返回
Google圖書搜尋
Serotonin Antagonism Improves Platelet Inhibition in Clopidogrel Low-responders After Coronary Stent Placement
Daniel Frank Dürschmied
Ingo Ahrens
Maximilian Mauler
Christoph Bode
Martin Moser
其他書名
An in Vitro Pilot Study
出版
Universität
, 2012
URL
http://books.google.com.hk/books?id=9txmtAEACAAJ&hl=&source=gbs_api
註釋
Abstract: Increased residual platelet reactivity remains a burden for coronary artery disease (CAD) patients who received a coronary stent and do not respond sufficiently to treatment with acetylsalicylic acid and clopidogrel. We hypothesized that serotonin antagonism reduces high on-treatment platelet reactivity. Whole blood impedance aggregometry was performed with arachidonic acid (AA, 0.5 mM) and adenosine diphosphate (ADP, 6.5 μM) in addition to different concentrations of serotonin (1-100 μM) in whole blood from 42 CAD patients after coronary stent placement and 10 healthy subjects. Serotonin increased aggregation dose-dependently in CAD patients who responded to clopidogrel treatment: After activation with ADP, aggregation increased from 33.7±1.3% to 40.9±2.0% in the presence of 50 μM serotonin (p
