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Spinal Cord Motion Assessed by Phase-contrast MRI - an Inter-center Pooled Data Analysis

Katharina WolfNikolai PfenderMarkus HuppMarco ReisertAxel Joachim KrafftReto SutterMarc HohenhausHorst UrbachMazda FarshadArmin Curt

出版	Universität, 2023
URL	http://books.google.com.hk/books?id=A6fgzwEACAAJ&hl=&source=gbs_api

註釋Abstract: Background

Phase-contrast MRI of CSF and spinal cord dynamics has evolved among diseases caused by altered CSF volume (spontaneous intracranial hypotension, normal pressure hydrocephalus) and by altered CSF space (degenerative cervical myelopathy (DCM), Chiari malformation). While CSF seems to be an obvious target for possible diagnostic use, craniocaudal spinal cord motion analysis offers the benefit of fast and reliable assessments. It is driven by volume shifts between the intracranial and the intraspinal compartments (Monro-Kellie hypothesis). Despite promising initial reports, comparison of spinal cord motion data across different centers is challenged by reports of varying value, raising questions about the validity of the findings.
Objective

To systematically investigate inter-center differences between phase-contrast MRI data.
Methods

Age- and gender matched, retrospective, pooled-data analysis across two centers: cardiac-gated, sagittal phase-contrast MRI of the cervical spinal cord (segments C2/C3 to C7/T1) including healthy participants and DCM patients; comparison and analysis of different MRI sequences and processing techniques (manual versus fully automated).
Results

A genuine craniocaudal spinal cord motion pattern and an increased focal spinal cord motion among DCM patients were depicted by both MRI sequences (p 0.01). Higher time-resolution resolved steeper and larger peaks, causing inter-center differences (p 0.01). Comparison of different processing methods showed a high level of rating reliability (ICC 0.86 at segments C2/C3 to C6/C7).brDiscussionbr