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Chapter 9. Cancer Pathogenesis and DNA Sensing
出版Elsevier Inc. Chapters, 2013-10-30
主題Medical / ImmunologyScience / Life Sciences / Microbiology
ISBN01280688259780128068823
URLhttp://books.google.com.hk/books?id=ADN3DAAAQBAJ&hl=&source=gbs_api
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註釋Toll-like receptors, NOD-like receptors and numerous intracellular sensors that detect nucleotides in the cytosol help to initiate immune responses to viral infections. Many of the cytosolic nucleotide sensors and their downstream mediators also play a role in RNA metabolism, DNA repair and cancer. Here we review the evidence that links cytosolic DNA sensors to processes that are activated in cancer cells.