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4. Chronic low-grade inflammation
出版Elsevier Inc. Chapters, 2013-09-30
主題Medical / Nutrition
ISBN01280869639780128086964
URLhttp://books.google.com.hk/books?id=AJB1DAAAQBAJ&hl=&source=gbs_api
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註釋Obesity is associated with chronic low-grade inflammation which results in insulin resistance, type 2 diabetes, vascular disease, chronic renal failure, several cancers and endocrine and behavioural abnormalities. The enlarged white adipocytes of the obese are now considered to be the initiators of chronic low-grade inflammation. Indeed, the gradual accumulation of triglycerides within adipocytes shifts their phenotype towards a pro-inflammatory one and at the same time accelerates their apoptosis. The hyperplastic white trunkal adipocytes of obesity produce large amounts of pro-inflammatory cytokines, acute-phase proteins and chemokines which attract circulating monocytes into adipose tissue and induce their activation to macrophages which intensify further and expand the adipose tissue inflammation.