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Process for the Preparation of O-desmethylvenlafaxine Salts

Silvo ZupančičFranc VrečerVida ŠkrabanjaMiran HvalecMatej SmrkoljTamara German

其他書名	EP20080009046, Filling Date 14.05.2009 : Appl. No. WO2009138234 (A1) : Applicant: Krka, Tovarna Zdravil, D.d. Novo Mesto
出版	European Patent Office, 2009
URL	http://books.google.com.hk/books?id=ALVFMwEACAAJ&hl=&source=gbs_api

註釋The present invention relates to a process for the preparation of a salt of O-desmethylvenlafaxine comprising a) dissolving or suspending O-desmethylvenlafaxine in the form of its base in a liquid medium selected from the group of solvents and suspending agents, - b) contacting O-desmethylvenlafaxine with a pharmaceutically acceptable acid to form a pharmaceutically acceptable salt of O-desmethylvenlafaxine wherein the pharmaceutically acceptable acid is selected from the group consisting of HCl, HBr, H2SO4, H3PO4, acetic acid, adipic acid, galactaric acid, D-gluconic acid, glutamic acid, glutaric acid, glycolic acid, hippuric acid, lactic acid, oxalic acid, methanesulphonic acid, ethanesulphonic acid, p- toluenesulphonic acid, camphorsulphonic acid, benzenesulphonic acid, malonic acid, L-ascorbic acid, naphtalene-2-sulfonic acid and benzoic acid; and c) separating the pharmaceutically acceptable salt of 0- desmethylvenlaf axine from the liquid medium to recover the salt, and to pharmaceutical formulations containing these salts.