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Autoantibodies in Silicosis Patients
Takemi Otsuki
Yasumitsu Nishimura
Kozo Urakami
Masayasu Kusaka
Nagisa Sada
Kei Yoshitome
Hidenori Matsuzaki
Naoko Kumagai-Takei
Hiroaki Hayashi
其他書名
Silica-Induced Dysregulation of Autoimmunity
出版
2019
主題
Medical / Immunology
URL
http://books.google.com.hk/books?id=Ab4g0AEACAAJ&hl=&source=gbs_api
註釋
Silica particles cause silicosis (SIL) and represent one of the most typical environmental and occupational substances that induce autoimmune disorders among the exposed population. Anti-nuclear antibody (ANA), anti-Sj√∂gren,Äôs-syndrome-related antigen A (SS-A), anti-centromere protein B (CENP)-B, and anti-scleroderma (Scl)-70 autoantibodies were examined in SIL and compared with those in healthy volunteers (HV) and patients with systemic sclerosis (SSc). Individuals with SIL were prone to autoimmune diseases and some autoantibodies seemed to be important as an estimation of this condition. Anti-Fas autoantibody found in SIL was functionally capable of inducing apoptosis in Fas-expressing cells, and this may cause a decrease of regulatory T cells (Tregs) expressing Fas in SIL.¬†Moreover, responder T cells (Tresps) in SIL seemed to be activated chronically and protected from Fas-mediated apoptosis. Thus, an imbalance of Tresps (dominant) and Tregs (less) occurred in SIL.¬†All of these causes of SIL are ready to further develop autoimmune diseases.