登入選單

返回Google圖書搜尋

BW 373U86: BEHAVIORAL PHARMACOLOGY OF A PUTATIVE NON-PEPTIDE, SYSTEMICALLY-ACTIVE DELTA OPIOID AGONIST.

SANDRA DEAN COMER

出版	University of MICHIGAN, 1992
URL	http://books.google.com.hk/books?id=Ak4eAQAAMAAJ&hl=&source=gbs_api

註釋

Convulsant effects of BW were evaluated in mice. NTI was 10-fold more potent than NTX in antagonizing BW. None of the opioid compounds tested, including the prototypic $\delta$ agonists, produced a convulsive syndrome that was similar to BW-induced convulsions. Pretreatment with BW produced a dose-related downward shift in the BW dose-effect curve. The downward shift produced by pretreatment with 10.0 mg/kg BW did not return to baseline levels for 8 days. This downward shift was prevented by both NTI