登入
選單
返回
Google圖書搜尋
Acute Megakaryoblastic Leukaemia Shows High Frequency of Chromosome 1q Aberrations and Dismal Outcome
Friederike Pastore
Hanna Gittinger
Susanne Raab
Sebastian Tschuri
Bianka Ksienzyk
Nikola P. Konstandin
Stephanie Schneider
Maja Rothenberg-Thurley
Hans-Peter Horny
Martin Werner
Maria C. Sauerland
Susanne Amler
Dennis Görlich
Wolfgang E. Berdel
Bernhard Wörmann
Jan Braess
Wolfgang Hiddemann
Johanna Tischer
Tobias Herold
Klaus Hans Metzeler
Karsten Spiekermann
出版
Universität
, 2023
URL
http://books.google.com.hk/books?id=Aq1t0AEACAAJ&hl=&source=gbs_api
註釋
Abstract: Acute megakaryoblastic leukaemia (AMKL) is associated with poor prognosis. Limited information is available on its cytogenetics, molecular genetics and clinical outcome. We performed genetic analyses, evaluated prognostic factors and the value of allogeneic haematopoietic stem cell transplantation (allo-HSCT) in a homogenous adult AMKL patient cohort. We retrospectively analysed 38 adult patients with AMKL (median age: 58 years, range: 21-80). Most received intensive treatment in AML Cooperative Group (AMLCG) trials between 2001 and 2016. Cytogenetic data showed an accumulation of adverse risk markers according to ELN 2017 and an unexpected high frequency of structural aberrations on chromosome arm 1q (33%). Most frequently, mutations occurred in TET2 (23%), TP53 (23%), JAK2 (19%), PTPN11 (19%) and RUNX1 (15%). Complete remission rate in 33 patients receiving intensive chemotherapy was 33% and median overall survival (OS) was 33 weeks (95% CI: 21-45). Patients undergoing allo-HSCT (n = 14) had a superior median OS (68 weeks; 95% CI: 11-126) and relapse-free survival (RFS) of 27 weeks (95% CI: 4-50), although cumulative incidence of relapse after allo-HSCT was high (62%). The prognosis of AMKL is determined by adverse genetic risk factors and therapy resistance. So far allo-HSCT is the only potentially curative treatment option in this dismal AML subgroup