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註釋COVID-19 has become a global public health problem, and the success of containment measures and public policies are subject to people's perception of the risk of the pandemic. This study aims to highlight the perception of risk of infection by COVID-19 in the Brazilian population, its vulnerabilities, and associated factors. This is a cross-sectional, descriptive, and analytical study via a web survey. The survey was conducted from August 2020 to February 2021, based on a non-probability snowball sampling. Descriptive and binary logistic regression analyses were performed using univariate and multivariate models. A total of 1,516 individuals from the five macro-regions of Brazil participated in the study. Individuals aged 40 to 59 years, black and using the Unified Health System (SUS) presented a higher odds of the perceived risk of infection by COVID-19. Those aged 40 to 59 years, 60 years or older, and who used the SUS showed higher odds for the perceived risk of developing severe disease or complication by COVID-19, while post-graduate level or more and complete higher education was associated with lower odds. Black participants, those aged 60 years or older, and women presented higher odds for the perceived risk of the population becoming infected with COVID-19, while graduate-level or more reduced the odds. This study's results highlight associations between the population's socioeconomic characteristics and perceived risk for infection with COVID-19. The perception of risk to one's health and collective health play an indispensable role in limiting the spread of infection, as do other factors.