登入選單

返回Google圖書搜尋

Prognostic Value of Tumor-infiltrating Immune Cells and Immune Checkpoints in Elderly Head-and-neck Squamous Cell Carcinoma Patients Undergoing Definitive (chemo)radiotherapy

Alexander RühleJovan TodorovicSimon Konrad Benedict SpohnEleni GkikaChristoph BeckerAndreas KnopfConstantinos ZamboglouTetyana SpraveMartin WernerAnca-Ligia GrosuGian KayserNils Nicolay

出版	Universität, 2022
URL	http://books.google.com.hk/books?id=BXqZzwEACAAJ&hl=&source=gbs_api

註釋

Abstract: Background and purpose

Tumor-infiltrating lymphocytes (TILs) are associated with locoregional control (LRC) in head-and-neck squamous cell carcinoma (HNSCC) patients undergoing (chemo)radiotherapy. As immunosenescence results in reduced immune activity, the role of TILs in elderly HNSCC patients may differ compared to younger patients, providing a rationale to study the prognostic role of TILs and immune checkpoints (ICs) in this population.
Material and methods

Sixty-three HNSCC patients aged ≥ 65 years undergoing definitive (chemo)radiotherapy between 2010 and 2019 with sufficient material from pre-treatment biopsies were included in the analysis. Immunohistochemical stainings of CD3, CD4, CD8, PD-L1, TIM3, LAG3, TIGIT and CD96, and of osteopontin as an immunosenescence-associated protein were performed. Overall survival (OS) and progression-free survival (PFS) were determined using the Kaplan-Meier method, and Fine-Gray's models were used for locoregional failure (LRF) analyses.
Results

While there was no correlation between patient age and IC expression, osteopontin levels correlated with increasing age (r = 0.322, p 0.05). Two-year OS, PFS, and LRC were 44%, 34%, and 71%, respectively. Increased LAG3 expression, both intraepithelial (SHR = 0.33, p 0.05) and stromal (SHR = 0.38, p 0.05), and elevated stromal TIM3 expression (SHR = 0.32, p