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Current Concepts of Acute Carbon Tetrachloride Hepatotoxicity

Philips W. Andrews

出版	USAF School of Aerospace Medicine, Aerospace Medical Division (AFSC), 1963
URL	http://books.google.com.hk/books?id=C6-rKvfAb4wC&hl=&source=gbs_api
EBook	FULL_PUBLIC_DOMAIN

註釋

A literature survey of hydrocarbon-induced, experimental, acute hepatotoxicity was made. It was concluded that carbon tetrachloride, and probably other hydrocarbons, directly interfere with the selective permeability of the liver cell wall and membranous endoplasmic reticulum for electrolytes, water, and certain hydrophilic proteins. Concomitantly the toxin stimulates the sympathetic nervous system and the release of its hormones. These reduce hepatic blood flow, by vasoconstriction, thereby inducing centrilobular hypoxia, degeneration, and necrosis. These also cause massive mobilization of fats from the peripheral depots. These fats accumulate in the liver where their secretion, as triglycerides, is blocked by unknown mechanisms. (Author).