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Genomic Perl
Rex A. Dwyer
其他書名
From Bioinformatics Basics to Working Code
出版Cambridge University Press, 2003
主題Computers / Languages / GeneralComputers / Languages / PerlComputers / Data Science / BioinformaticsScience / BiotechnologyScience / Life Sciences / Molecular BiologyScience / Bioinformatics
ISBN052180177X9780521801775
URLhttp://books.google.com.hk/books?id=C88KrD4enWkC&hl=&source=gbs_api
EBookSAMPLE
註釋This introduction to computational molecular biology will help programmers and biologists learn the skills needed to start work in this important, expanding field. The author explains many of the basic computational problems and gives concise, working programs to solve them in the Perl programming language. With minimal prerequisites, the author explains the biological background for each problem, develops a model for the solution, then introduces the Perl concepts needed to implement the solution. The book covers pairwise and multiple sequence alignment, fast database searches for homologous sequences, protein motif identification, genome rearrangement, physical mapping, phylogeny reconstruction, satellite identification, sequence assembly, gene finding, and RNA secondary structure. The concrete examples and step-by-step approach make it easy to grasp the computational and statistical methods, including dynamic programming, branch-and-bound optimization, greedy methods, maximum likelihood methods, substitution matrices, BLAST searching, and Karlin-Altschul statistics. Perl code is provided on the accompanying CD.