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Crossing the Boundaries of Life
Karl S. Matlin
其他書名
Günter Blobel and the Origins of Molecular Cell Biology
出版
University of Chicago Press
, 2022-05-10
主題
Science / General
Science / History
Science / Life Sciences / Cell Biology
Biography & Autobiography / Science & Technology
ISBN
0226819353
9780226819358
URL
http://books.google.com.hk/books?id=CvVlEAAAQBAJ&hl=&source=gbs_api
EBook
SAMPLE
註釋
A close look at Günter Blobel’s transformative contributions to molecular cell biology.
The difficulty of reconciling chemical mechanisms with the functions of whole living systems has plagued biologists since the development of cell theory in the nineteenth century. As Karl S. Matlin argues in
Crossing the Boundaries of Life
, it is no coincidence that this longstanding knot of scientific inquiry was loosened most meaningfully by the work of a cell biologist, the Nobel laureate Günter Blobel. In 1975, using an experimental setup that did not contain any cells at all, Blobel was able to target newly made proteins to cell membrane vesicles, enabling him to theorize how proteins in the cell distribute spatially, an idea he called the signal hypothesis. Over the next twenty years, Blobel and other scientists were able to dissect this mechanism into its precise molecular details. For elaborating his signal concept into a process he termed
membrane topogenesis
—the idea that each protein in the cell is synthesized with an "address" that directs the protein to its correct destination within the cell—Blobel was awarded the Nobel Prize in Physiology or Medicine in 1999.
Matlin argues that Blobel’s investigative strategy and its subsequent application addressed a fundamental unresolved dilemma that had bedeviled biology from its very beginning—the relationship between structure and function—allowing biology to achieve mechanistic molecular explanations of biological phenomena.
Crossing the Boundaries of Life
thus uses Blobel’s research and life story to shed light on the importance of cell biology for twentieth-century science, illustrating how it propelled the development of adjacent disciplines like biochemistry and molecular biology.