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Druggability Evaluation of the Neuron Derived Orphan Receptor (NOR-1) Reveals Inverse NOR-1 Agonists

Daniel ZaienneSilvia ArifiJulian MarschnerJan Peter HeeringDaniel Merk

出版	Wiley-VCH, 2022
URL	http://books.google.com.hk/books?id=FW8H0AEACAAJ&hl=&source=gbs_api

註釋

The neuron derived orphan receptor (NOR-1, NR4A3) is among the least studied nuclear receptors. Its physiological role and therapeutic potential remain widely elusive which is in part due to the lack of chemical tools that can directly modulate NOR-1 activity. To probe the possibility of pharmacological NOR-1 modulation, we have tested a drug fragment library for NOR-1 activation and repression. Despite low hit-rate (