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Molecular Exploitation of Apoptosis Pathways in Prostate Cancer
Natasha Kyprianou
出版World Scientific, 2012
主題Medical / Oncology / GeneralMedical / Oncology / Prostate CancerMedical / UrologyScience / Life Sciences / Cell Biology
ISBN18481644919781848164499
URLhttp://books.google.com.hk/books?id=GP0xkFW2YUwC&hl=&source=gbs_api
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註釋This book focuses on the functional significance of targeting apoptosis for the treatment of prostate cancer. New concepts on the challenges relating to the development of resistance by androgen-independent tumors are introduced, in terms of the contribution of anoikis and cross-talk of androgens with key growth factor signaling pathways. This volume also provides insightful discussion on the exploitation of the apoptotic and angiogenic synergism towards complete eradication of prostate tumors. Last but not least, it includes reflections on the drug development challenge based on the analysis of data from existing clinical trials.