返回Google圖書搜尋

Diffusion Tensor Imaging in Unclear Intramedullary Tumor-suspected Lesions Allows Separating Tumors from Inflammation

Marc HohenhausYorn MerzJan-Helge KlinglerChristoph ScholzUlrich HubbeJürgen BeckKatharina WolfKarl EggerMarco ReisertNico Kremers

出版	Universität, 2021
URL	http://books.google.com.hk/books?id=GsUb0AEACAAJ&hl=&source=gbs_api

註釋Abstract: Design
Prospective diagnostic study.

Objectives
Primary imaging-based diagnosis of spinal cord tumor-suspected lesions is often challenging. The identification of the definite entity is crucial for dedicated treatment and therefore reduction of morbidity. The aim of this trial was to investigate specific quantitative signal patterns to differentiate unclear intramedullary tumor-suspected lesions based on diffusion tensor imaging (DTI).

Setting
Medical Center - University of Freiburg, Germany.

Methods
Forty patients with an unclear tumor-suspected lesion of the spinal cord prospectively underwent DTI. Primary diagnosis was determined by histological or clinical work-up or remained indeterminate with follow-up. DTI metrics (FA/ADC) were evaluated at the central lesion area, lesion margin, edema, and normal spinal cord and compared between different diagnostic groups (ependymomas, other spinal cord tumors, inflammations).

Results
Mean DTI metrics for all spinal cord tumors (n = 18) showed significantly reduced FA and increased ADC values compared to inflammatory lesions (n = 8) at the lesion margin (p 0.001, p = 0.001) and reduced FA at the central lesion area (p 0.001). There were no significant differences comparing the neoplastic subgroups of ependymomas (n = 10) and other spinal cord tumors (n = 8), but remaining differences for both compared to the inflammation subgroup. We found significant higher ADC (p = 0.040) and a trend to decreased FA (p = 0.081) for ependymomas compared to inflammations at the edema.br