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Looking at the Parameters Available on the Heidelberg Retina Tomograph

其他書名	How Much Change Between Scans is Significant?
出版	Northeastern State University, 2003
URL	http://books.google.com.hk/books?id=I7nFnQAACAAJ&hl=&source=gbs_api

註釋Purpose: To determine how much change is normal and how much suggests glaucoma progression in an optic nerve head from a baseline to a follow-up analysis as measured by the Heidelberg Retina Tomograph (HRT). Methods: In an HRT records review, change was calculated between baseline and follow-up scans on subjects that met a specific criteria set. Statistical analysis was then used to determine how much change was significant. Regression coefficients were calculated for those parameters in which a significant number of subjects demonstrated change. Parameters analyzed included: the global and sectoral rim area, cup volume, cup shape measure, and retinal nerve fiber layer thickness. Results: Cut-off values for the amount of change to be significant (pd".05 and pd".01)in all parameters were determined. Eight of thirty parameters had enough subjects to calculate regression coefficients. Of those, change in temporal rim area correlated best with time ( -0.804). Conclusion: The diagnosis of glaucoma is more accurate when change between baseline and follow-up scans is considered rather than a single scan in time diagnosed using a statistical package included in the HRT. Change in temporal rim area was shown to be the best indicator of progression in early glaucoma, but loses its diagnostic value in later stages. Even though the HRT is an excellent source of quantitative measurements, its key value is in conjunction with the current methods of monitoring glaucomatous progression.