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Parental Obesity Predisposition and Age of Onset Associate with Poor Response to Bariatric and Metabolic Surgery

Mira FinkStephan HerrmannJodok Matthias FinkClaudia LäßleGoran MarjanovicLuca FagnocchiJ. Andrew PospisilikStefan Fichtner-FeiglGabriel Seifert

出版	Universität, 2023
URL	http://books.google.com.hk/books?id=Ip0K0AEACAAJ&hl=&source=gbs_api

註釋Abstract: Introduction
Parental predisposition and age of onset may be independently associated with 1-year total weight loss (TWL) failure ( 20%) after metabolic-bariatric surgery (MBS).brbrMethodsbrThis cohort study includes all cases of the German StuDoQ|MBE register (2015-2019) with data on parental predisposition, obesity onset, and at least 1-year follow up after primary MBS procedures (n = 14,404). We provide descriptive statistics of the cohort in terms of the main outcome and 1-year TWL failure, and provide characteristics of surgery type subgroups. Finally, we provide a multivariate logistic regression model of 1-year TWL failure.brbrResultsbr58.8% and 45.7% of patients reported maternal and paternal predisposition for obesity, respectively. Average onset of obesity was 15.5 years and duration of disease 28.3 years prior to MBS. SG is the most frequently performed procedure (47.2%) followed by RYGB (39.7%) and OAGB (13.1%). Mean 1-year TWL is 32.7 ± 9.3%, and 7.8% (n = 1,119) of patients show TWL failure ( 20%). Multivariate analysis shows independent association of early onset of obesity ( 18 years), male sex, age at operation, pre-operative BMI, pre-operative weight loss, sleeve gastrectomy (SG), and type 2 diabetes (T2D) with 1-year TWL failure (p