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Nitrene Generation Via Visible-light Photocatalysis

其他書名	Aziridination From Electrophilic Amine Sources
出版	Bard College, 2019
URL	http://books.google.com.hk/books?id=JVK00AEACAAJ&hl=&source=gbs_api

註釋Carbon-nitrogen bonds (C-N) bonds are ubiquitous in both natural and unnatural small molecules, especially those with potential bioactivity. This work is focused on the development of new methods for C-N bond formation, specifically aziridines, via nitrene intermediates through metal-mediated visible-light photocatalysis. Iridium bypyridyl complexes have been shown to mediate this generation of nitrenes from stabilized azides (azidoformates), which can then be transferred to alkenes to afford aziridines. To better understand this process, we have prepared alternatives to the azidoformate precursor: N-tosyloxy carbamates and N-protected aminopyridinium salts. A study of the nature of the nitrene precursor, metal catalyst, reaction conditions and rate of product formation is explored in aziridination under visible light photocatalysis.