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Effects of Citrus Juices and Constituent Flavonoids on Lipid and Lipoprotein Metabolism [microform] : in Vivo and in Vitro Studies

Nica Maria Borradaile

出版	Thesis (M.Sc.)--University of Western Ontario, 1998
ISBN	06123075819780612307582
URL	http://books.google.com.hk/books?id=JnOxSgAACAAJ&hl=&source=gbs_api

註釋

To determine whether the changes observed in rabbits were due to flavonoids present in the juices acting directly on the liver, the effects of hesperetin and naringenin (aglycone forms of hesperidin and naringin, respectively) on net apoB secretion by HepG2 cells were investigated. The flavonoids dose-dependently reduced net apoB secretion by up to 81% after a 24h exposure. Further studies showed that net apoB secretion by the cells was significantly reduced by 50% after a 4h exposure to 60$\mu$g/ml of either hesperetin or naringenin. Since the reduction in net apoB secretion occurred after a brief exposure to the flavonoids, we investigated whether the effects could be (i) due to increased proteasomal degradation of apoB prior to secretion, or (ii) due to altered lipid availability during the early stages of lipoprotein assembly. (Abstract shortened by UMI.).