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Endocannabinoid Metabolism in Posttraumatic Stress Disorder

其他書名	Preliminary Results from a Neuroimaging Study with the Novel Fatty Acid Amide Hydrolase Probe [C-11] CURB.
出版	University of Toronto, 2020
URL	http://books.google.com.hk/books?id=KVVPzwEACAAJ&hl=&source=gbs_api

註釋Background: Preclinical studies suggest that levels of Fatty Acid Amide Hydrolase (FAAH)-the catabolic enzyme for the endocannabinoid anandamide-may be elevated in the amygdala in posttraumatic stress disorder (PTSD). However, the status of FAAH in vivo in posttraumatic stress disorder remains unknown. Methods: Healthy subjects (n=29) and individuals with PTSD (n=16) completed a positron emission tomography scan following injection of the FAAH probe [C-11]CURB. Results: We find no evidence for elevated [C-11]CURB binding in PTSD. Instead, we find marginally lower [C-11]CURB binding in whole brain (-9.38%, p=0.079) and significantly lower [C-11]CURB binding in the amygdala (-14.50%, p=0.020) in PTSD subjects. [C-11]CURB binding did not correlate with PTSD symptomatology. Conclusion: Our data provide preliminary evidence contrary to preclinical literature, suggesting that FAAH may be lower in people with PTSD. These findings have implications for treatment strategies targeting this enzyme (i.e. FAAH inhibitors) in PTSD.