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Immune system disorders: from molecular mechanisms to clinical implications
Mauricio César De MarziMarisa Mariel FernandezRuben Dario Motrich Matias Ostrowski
出版Frontiers Media SA, 2024-10-17
主題Medical / General
ISBN28325550559782832555057
URLhttp://books.google.com.hk/books?id=KmoqEQAAQBAJ&hl=&source=gbs_api
EBookSAMPLE
註釋In recent years, the increase in knowledge about the functioning of the immune system has revealed not only its importance in the defense against external agents such as pathogens or toxins, but also in the control of tumor cells and the importance of the processes of inflammation or immunological tolerance. On the one hand, all this knowledge has allowed a better understanding of the putative pathogenic consequences of immune system dysfunction, which includes inflammatory, autoimmune and immunosuppressive diseases, among others. On the other hand, current knowledge about immunoregulation has paved the way to better prevent or control transplantation rejection. However, such mechanisms underlying immune dysregulation are highly variable depending on the type of pathology (systemic chronic inflammatory diseases, autoinflammatory diseases, autoimmune disorders, immunosuppression) and on characteristics of the host such as sex, genetics, nutritional status, etc. Given the wide variety of pathologies that are a consequence of excessive, inefficient or inadequate induction of immune responses, the study of factors involved in the dysregulation of the immune system has gained great attention during the last decades.