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The Role of Substance P and Its Receptor NK1R in Chronic Prurigo: Results from a Randomized, Controlled Trial with Topical Aprepitant

出版	Morressier, 2017
URL	http://books.google.com.hk/books?id=MWSzzQEACAAJ&hl=&source=gbs_api

註釋Substance P (SP) and its receptor neurokinin 1 (NK1R) are held to be involved in the pathogenesis of chronic prurigo (CPG). Here, we assessed SP serum levels, cutaneous NK1R expression, and the effects of topical aprepitant, an NK1R antagonist, in CPG patients. SP and NK1R were increased, as compared to controls, in the serum and in lesional vs. non-lesional skin of CPG patients, respectively. Aprepitant, in a randomized, placebo-controlled, split-sided, double-blind trial, reduced pruritus intensity as assessed by visual analogue scale by >50% from baseline to day 28 (-35.2), but so did placebo vehicle (-38.1, P=0.76). Overall CPG scores improved significantly by day 28 in both treatment groups, with no significant difference between the two (P=0.32). Our findings imply both SP and NK1R are involved in the pathogenesis of CPG. Parallel group-designed trials are needed to assess the efficacy of topical aprepitant treatment in CPG.