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Renal Tubular Transport of Amino Acids and Phosphate in Normal and Mutant States

Roderick R. McInnes

出版	Thesis (Ph.D.)--McGill University, 1978
URL	http://books.google.com.hk/books?id=MuKgnQEACAAJ&hl=&source=gbs_api

註釋

The pathophysiology of the major inborn errors of renal transport in man, is reviewed and summarized. The experimental sections describe: 1) the mutant Hyp mouse with X-linked hypophosphatemia and evidence for an intrinsic defect in net tubular reabsorption of phosphate anion; 2) the PRO/Re mouse with autosomal recessive proline oxidase deficiency and evidence that intracellular oxidation of solute comes to influence its transepithelial reabsorption; 3) renal handling of the inert amino acid a-aminoisobutyric acid (AIB) and of phosphate by the rat in vivo. The latter investigations show that AIB is transported by carriers serving the natural L-amino acids. It equilibrates slowly with an intrarenal pool so as to achieve significant cell-to-lumen flux at steady-state. Whereas bovine parathyroid extract enhances fractional excretion of phosphate in the intact and TPTX rat, AIB excretion is not similarly affected in the TPTX rat. [...].